Research identifies associations between urinary metals and cardiovascular disease (CVD) as well as all-cause mortality. The findings suggest that both essential and non-essential metals in urine can serve as risk factors for CVD and mortality, emphasizing the need for strategies to mitigate these risks.
By Dr. Priyom Bose, Ph.D.Reviewed by Benedette Cuffari, M.Sc.Aug 5 2024 A recent Circulation journal study evaluates the association between urinary metals, cardiovascular disease , and all-cause mortality.
The American Heart Association has recognized arsenic, cadmium, and lead as CVD risk factors. However, there remains a lack of evidence on how low levels of exposure to heavy metals may contribute to the risk of CVD. Likewise, few studies have assessed the impact of essential metals, such as cobalt, copper, and zinc, as well as non-essential metals, like uranium and tungsten, on the risk of CVD.
These individuals were more likely to have hypertension or diabetes or be current smokers. Study participants who experienced a CVD event during the follow-up period had higher baseline levels of zinc, copper, cadmium, and tungsten. A linear dose-response curve was observed for cobalt, cadmium, and copper with CVD. Comparatively, a positive association was only observed between CVD risk and high levels of tungsten, uranium, and zinc.
Fully adjusted models showed an increased risk of all-cause mortality associated with higher baseline urinary levels of all six metals. Comparing the highest with the lowest quartiles of urinary metals, aHRs were highest for cadmium and lowest for tungsten.
Mortality Arsenic Atherosclerosis Copper Heart Inflammation Oxidative Stress Stress Zinc
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