Brown fat is a 'nutrient sink' that could play an important role in glucose and even glutamate metabolism, and may offer a target for tackling obesity and potentially even cancer, suggests US research.
, was led by David A. Guertin, PhD, Program in Molecular Medicine, UMass Chan Medical School, Worcester, Massachusetts.
Intriguingly, clinical data show that the more BAT you have, the more likely you are to be protected against cardiometabolic disorders associated with obesity. In addition, circulating metabolites sometimes also have messenger functions, similar to those of hormones, that stimulate physiologic processes such as adaptative thermogenesis. Highly metabolic tissues also put metabolites back into the blood, which can send messages to the brain and other tissues.
We need to know that information so that therapeutic strategies targeting brown adipocytes can be optimized to have the best chance of success. Another big challenge with comparing humans and mice is that humans typically keep their environment warm, so their brown fat is not that active.
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