Unlocking Memory: Neuroscientists Reveal How the Brain Decides What To Remember

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Unlocking Memory: Neuroscientists Reveal How the Brain Decides What To Remember
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Science, Space and Technology News 2024

Neuroscientists have determined that some daily experiences are transformed into permanent memories during sleep through a process facilitated by the brain. A recent study led by NYU Grossman School of Medicine has identified “sharp wave-ripples” in the hippocampus as the key mechanism that selects which memories to retain permanently.

Called “sharp wave-ripples,” these “shouts” to the rest of the brain represent the near-simultaneous firing of 15 percent of hippocampal neurons, and are named for the shape they take when their activity is captured by electrodes and recorded on a graph., found that daytime events followed immediately by five to 20 sharp wave-ripples are replayed more during sleep and so consolidated into permanent memories. Events followed by very few or no sharp wave-ripples failed to form lasting memories.

Importantly, sharp wave-ripples are known to be made up the firing of hippocampal “place cells” in a specific order that encodes every room we enter, and each arm of a maze entered by a mouse. For memories that are remembered, those same cells fire at high speed, as we sleep, “playing back the recorded event thousands of times per night.” The process strengthens the connections between the cells involved.

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