Research achieves scientific breakthrough in understanding cell division.
An international research collaboration, led by Prof. Dr. Robert Grosse , Dr. Libor Macurek and Dr. Zdenek Lansky has uncovered a new mechanism of the crosstalk between microtubules and actin cytoskeleton during cell division and revealed unique characteristics of the previously unexplored protein FAM110A.
Until recently, scientists believed that actin filaments are needed only for the final step of daughter cell separation and the role of actin cytoskeleton in mitosis has long been neglected. In their latest study, the research team now demonstrates that the previously unexplored protein FAM110A has unique properties that enable it to bind actin and microtubules at opposite ends, specifically at the poles of the mitotic spindles.
Cell division ensures growth or renewal and is thus vital for all organisms. However, the process differs somewhat in animals, bacteria, fungi, plants, and algae. Until now, little was known about ...
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