An 'unexpected finding' has allowed scientists to link oestrogen deficiency to obesity in female mice, providing new insights for postmenopausal women. 9News
from Baker Heart and Diabetes Institute found a deficiency of oestrogen receptor alpha in the heart causes obesity in female mice but not in male mice.
"When we blocked this oestrogen receptor, we were expecting to see changes and damage largely to the heart but rather than seeing a dramatic heart phenotype, what we saw was an adiposity phenotype," lead author professor Julie McMullen said. "Rather than energy being expended, energy is instead stored, which explains the increased adiposity in female mice in the absence of ERα ."Once women are postmenopausal and oestrogen levels drop, they are at an increased risk of obesity and diabetesThe research has implications for preventing and treating heart and metabolic disease in postmenopausal women.
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