Several new drugs will soon be available that show greater effectiveness at treating -- and possible ending -- ulcerative colitis.
Dec. 6, 2024 — After a 15-year hiatus, one patient was happy to go hiking again. Another said, “I always kept track of where the bathrooms were on my trip to college.
The new medications will fill an unmet need, said Ali. While many medications for ulcerative colitis are on the market now, patients’ responses to specific medications tend to decline, so treatments need to be switched, and new approaches are always needed.More than 1.5 million people in North America have ulcerative colitis, making it the most common type of inflammatory bowel disease . It affects the inner lining of the colon and rectum, causing damage.
There are no head-to-head studies to compare the three IL-23 inhibitors, but the trials suggest that their effectiveness is comparable, said Ali. The IL-23 drugs “are typically given as a first dose by infusion, and later doses by an injection under the skin,” said Moss. “The dosing is only once every eight weeks after the first infusion, so this reduces the number of treatments per year a patient needs.”and later approved for IBD; it blocks both IL-23 and IL-12, another protein that in excess can cause inflammation and lead to ulcerative colitis. Now, the FDA has approved five biosimilars of Stelara; the most recent is Selarsdi .
As for those on Medicare and Medicaid, the rules and coverage vary, he said, “so patients will only know their coverage and copays when it’s prescribed and submitted to their insurance.”This wider range of medication options can help health care providers tailor the drug to an individual patient’s disease characteristics, Moss said.
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