A new study reveals that measuring Type I interferon (IFN) activity in the blood could predict how quickly limited cutaneous systemic sclerosis (lcSSc) progresses. Patients with higher IFN scores experienced more severe symptoms and a greater risk of complications.
A new study suggests that Type I interferon (IFN) activity, measured by a serum IFN score, could be a valuable tool for predicting disease progression in limited cutaneous systemic sclerosis (lcSSc). Patients with higher IFN scores experienced worse clinical outcomes, highlighting the potential of this biomarker in guiding treatment and management strategies.
Researchers conducted a longitudinal retrospective analysis involving 149 lcSSc patients (average age 60 years, 96% women, median disease duration 8 years) recruited between December 2013 and November 2019. The IFN score was calculated based on the concentration of six chemokines (CCL2, CCL8, CCL19, CXCL10, CXCL9, and CXCL11) in serum. A high IFN score was defined as two standard deviations above the mean score observed in 72 matched healthy control individuals. The primary outcome measure was time to clinical worsening, assessed using a composite Morbi-mortality endpoint that included disease-related mortality and organ manifestations. Patients with lcSSc had significantly higher serum chemokine concentrations compared to healthy controls, resulting in a significantly higher IFN score. Importantly, those with high IFN scores experienced a significantly shorter time to clinical worsening and faced a more than sixfold higher hazard of Morbi-mortality events compared to patients with low IFN scores. Other factors significantly associated with an increased likelihood of worsening clinical events included pulmonary artery hypertension, interstitial lung disease, digital ulcers, modified Rodnan skin score, and age. The authors concluded that type I IFN activation, reflected by the IFN score, may be a valuable tool for assessing disease activity and predicting clinically meaningful events in lcSSc
SYSTEMIC SCLEROSIS Lcssc INTERFERON BIOMARKER DISEASE PROGRESSION CLINICAL OUTCOMES
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