Large Korean study suggests sodium-glucose cotransporter-2 inhibitors, may prevent dementia
The research, published by the BMJ, also identified a 39% reduced risk for Alzheimer’s disease associated with SGLT-2 inhibitors.The research, published by the BMJ, also identified a 39% reduced risk for Alzheimer’s disease associated with SGLT-2 inhibitors.Type 2 diabetes is one of 14 risk factors associated with a greater risk of developing dementia.
While previous studies have suggested SGLT-2 inhibitors could have a protective effect against dementia for older patients, until now, any protective effect on younger people and specific types of dementia such as Alzheimer’s disease and vascular dementia has been unclear. Half were taking SGLT-2 inhibitors, which reduce the amount of glucose the kidneys reabsorb, and half were taking another drug called dipeptidyl peptidase 4 inhibitors, which block the enzyme that helps increase insulin levels after food.The researchers calculated SGLT-2 inhibitors were associated with a 35% lower risk of dementia compared with DPP-4 inhibitors.
Dr Jacqui Hanley, the head of research at Alzheimer’s Research UK, said the data was “promising”, adding: “People affected by dementia urgently need effective treatments, as last week’s news of
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