Simplified method using left atrial volume and natriuretic peptides streamlines diagnosis of heart failure with preserved ejection fraction.
Assessing left atrial volume and natriuretic peptides can identify heart failure with preserved ejection fraction with an 88% specificity and 97% positive predictive value. The strategy reduces the need for additional diagnostics by decreasing intermediate Heart Failure Association pre-test assessment, echocardiography & natriuretic peptide, functional testing, final etiology or H₂FPEF algorithm scores by 27%-56%.
in atrial fibrillation) and natriuretic peptides with data from 443 patients with suspected HFpEF and validated in two independent cohorts. End-systolic LA was manually traced in echocardiographic apical four- and two-chamber views and indexed for both body surface area and heightResearchers developed the simplified approach by determining abnormal values for each measure of LA based on the highest value in control individuals, stratified by sinus rhythm/atrial fibrillation, and using elevated natriuretic peptides based on the HFA-PEFF major criterion.The LA/NP approach identified 60% of HFpEF patients with an 88% specificity and a 97% positive predictive value in the derivation cohort, with similar results in the validation cohorts . The validation cohorts confirmed the LA/NP approach, with a 21%-57% reduction in intermediate scores, demonstrating consistent diagnostic accuracy across different clinical HFpEF profiles.with LA reservoir strain showed comparable results, suggesting flexibility in the echocardiographic parameters that can be used in this simplified diagnostic approach.FPEF algorithm as a second step may substantially reduce the need for additional diagnostics to diagnose HfpEF,” the researchers wrote. The study was led by Jerremy Weerts, MSc, MD, of Maastricht University Medical Center in Maastricht, the Netherlands. It was published online inThe analyses were performed retrospectively in three independent, prospective cohorts from university hospitals, each with a high prevalence of diagnosed HFpEF, which may affect the performance of the LA/NP approach in less selected populations. The use of different natriuretic peptide assays across cohorts limited the derivation of new cut-off values for the LA/NP approach. Right heart catheterization was not performed in all patients, although this reflects daily clinical practice and aligns with large clinical trials in HFpEF.Weerts reported receiving grants from Corvia Medical, CSL Vifor, and Boehringer Ingelheim, unrelated to the submitted work. The study was supported by the Dutch Heart Foundation and the Health Foundation Limburg. Additional disclosures are noted in the original article. This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.All material on this website is protected by copyright, Copyright © 1994-2025 by WebMD LLC. This website also contains material copyrighted by 3rd parties.
Heart Failure (HF) Cardiovascular Imaging Cardiac Imaging CV Imaging Heart Atrial Fibrillation AF Afib A-Fib Afib Afib Atrial Fib Atrial Fibrillation (AF) Atrial Fibrillation (A-Fib) Right Heart Catheterization Hypertension Ejection Fraction Left Ventricular Ejection Fraction LVEF Ejection Fraction (EF) Europe European Grant Sinus Otolaryngology ENT Specialty
United States Latest News, United States Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
How to Buy Ethereum: Step-by-Step GuideIn this guide, we will demonstrate the best ways to buy Ethereum with fiat and crypto
Read more »
‘I hate cold cuts’: U.S. Rep. Shontel Brown makes emotional plea against SNAP cutsCongresswoman shares how food assistance helped her family during childhood
Read more »
GOP’s SNAP Cuts Are Worse Than Its Medicaid CutsThe House version of Trump’s ‘big beautiful’ bill will include big cuts in the SNAP program that may be worse than its Medicaid cuts. Cost shifts to the states could lead to food stamp benefit losses for millions of low-income families.
Read more »
Trump's 'Big Beautiful Bill' passes House Budget Committee voteIt would fund tax cuts by slashing spending, including massive cuts to Medicaid.
Read more »
Cuts, chaos and hope: Voices from a town hall as Trump cuts ripple through Northeast OhioNortheast Ohioans voiced their fears and frustrations at a recent forum hosted by Cleveland.com.
Read more »
The Post's step-by-step blueprint for how the Knicks can save their seasonIt’s not over.
Read more »