Combining magnetic and direct current transcranial stimulations was more effective than either treatment alone for major depressive disorder.
Combining transcranial direct current stimulation and repetitive transcranial magnetic stimulation was associated with a greater reduction in symptoms of major depressive disorder than either treatment alone, a new study showed.Researchers conducted a double-blind, sham-controlled randomized clinical trial from 2021 to 2023 at three hospitals in China with 240 participants with MDD .
tDCS was administered in 20-minute sessions using a 2-mA direct current stimulator, whereas rTMS involved 1600 pulses of 10-Hz stimulation targeting the left dorsolateral prefrontal cortex. Sham treatments used a pseudostimulation coil and only emitted sound. Secondary outcomes included HDRS-24 total score change at week 4, remission rate , response rate , and adverse events.The active tDCS + active rTMS group demonstrated the greatest reduction in mean HDRS-24 score at week 2 compared with sham tDCS + active rTMS, active tDCS + sham rTMS, and sham tDCS + sham rTMS than in the active tDCS + sham rTMS and sham tDCS + sham rTMS groups .
Major Depressive Disorder Unipolar Depression Clinical Depression MDD Depression Brain Remission Antidepressant Antidepressant Drug Hospitals Repetitive Transcranial Magnetic Stimulation Rtms - Repetitive Transcranial Magnetic Stimulati Healthcare And Medical Technology Health And Medical Tech Health And Med Tech Health And Medical Technology Healthcare Technology
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