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Researchers at The Australian National University have developed a Trojan horse method that attaches cholesterol to drugs, effectively targeting and killing parasites like those causing malaria. This method not only promises more effective treatments by exploiting the parasites’ need for cholesterol but also has broader applications in treating other diseases and protecting livestock, potentially saving billions in agricultural losses.
The researchers have developed a trojan horse method that tricks malaria parasites into ingesting a fatal dose of drugs by exploiting the parasite’s need for cholesterol to survive. By attaching cholesterol to drugs, the scientists can “smuggle” the drugs into the parasite where they can exert their killing effect.
“Existing drugs used to treat malaria are taken up passively by the parasite, meaning they’re not as effective as they could be,” Professor Maier said. “This research also paves the way for the development of new, more efficient drugs that are also cheaper to manufacture.”According to the ANU scientists, this new drug delivery system of coupling drugs with cholesterol could also be used to treat other diseases including giardia, an intestinal disease responsible for causing diarrhea.
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