More than 11,000 people have died and thousands have lost homes following the earthquake.
DEC chief executive Saleh Saeed described the scenes in Turkey and Syria as "heartbreaking", with thousands "losing loved ones suddenly in the most shocking of ways".
Salah Aboulgasem, from the Islamic Relief charity, based in Gazientep, Turkey, added: "The priority right now is saving lives by clearing the rubble. The next priority is supporting people who have lost their homes and gone through huge trauma. Fourteen of the DEC's 15 members are either responding, or planning to respond, in Turkey and Syria and will receive funds from the appeal.
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