The comparative efficacy and tolerability of oral migraine medications suggest four triptans are superior to the newer, more expensive migraine medications, new research showed.
International guidelines generally endorse NSAID s as the first-line treatment for migraine and recommend triptans for moderate to severe episodes or when the response to NSAID s is insufficient.
The analysis included 137 double-blind, randomized controlled trials that were primarily sponsored by the pharmaceutical industry. It included 89,445 adult outpatients with migraine . While triptans are contraindicated in patients with vascular disease, the researchers noted that"cerebrovascular events may present primarily as migraine-like headaches, and misdiagnosis of transient ischemic attack and minor
The new results underscore the importance of head-to-head trials, which is the gold standard, said Cipriani. "Calling triptans the medication with the 'best profile' might be not applicable in many cases," she said. For example, those who need acute medication more than two to three times a week in addition to those with cardiovascular contraindications to triptans may fall outside of that category, Riggins noted.
Migraine Headache Tryptamines Triptan Pain Management Pain Headache Chest Pain Angina Angina Pectoris Clinical Guidelines Guidelines Nonsteroidal Anti-Inflammatory Drugs Nsaids NSAID Nonsteroidal Anti-Inflammatory Drugs Nonsteroidal Anti-Inflammatory Agents Treatment Guidelines
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