Researchers from the United States used a genetically engineered porcine donor to develop kidney grafts.
By Dr. Chinta SidharthanOct 11 2023Reviewed by Lily Ramsey, LLM In a recent study published in Nature, a team of researchers from the United States used a genetically engineered porcine donor to develop kidney grafts, which were then transplanted into a non-human primate model to test its life-supporting function in the long term.
While kidney tissues engineered in porcine donors have been tested in Old-World monkeys, and these studies have contributed significantly to understanding the challenges in xenotransplantation, these organs are not yet ready for clinical use. The grafts were also engineered to overexpress human transgenes. These renal grafts were transplanted into Macaca fascicularis or cynomolgus monkeys, which served as the non-human primate models to test the efficacy and safety of the renal grafts.
The nucleus from cells that were edited were subsequently used for somatic cell nuclear transfer to produce pigs that had these edits. The pigs made after SCNT were all female Yucatan miniature pigs . The kidney xenografts were transplanted into male and female M. fascicularis cynomolgus monkeys and postoperatively monitored through ultrasound, urine output, hematology, clinical chemistry, and histopathological analyses of renal biopsies.
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