A novel nanobody-based immunosensor, designed to function stably in undiluted biological fluids and harsh conditions, has been developed.
Their innovative design leverages BRET -- bioluminescence resonance energy transfer -- and exhibits great potential for point-of-care testing, therapeutic drug monitoring, and environmental applications using paper-based devices.
A particularly promising class of homogeneous immunosensors, known as Quenchbodies , work by emitting fluorescence in response to antigen binding. In their"quenched" state, Q-bodies remain inactive, but upon antigen binding, they undergo structural changes, leading to the emission of light by canceling of quenched state.
The process works as follows: when the target antigen binds to the nanobody, structural changes occur, which move the TAMRA dye away from the nanobody and closer to the NanoLuc enzyme. This change recovers the quenching of TAMRA and facilitates energy transfer between the two molecules, changing emission color from blue of the NanoLuc-catalyzed reaction to red of TAMRA.
Medical Imaging Pharmacology Personalized Medicine Chemistry Spintronics Biochemistry Medical Technology
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