Researchers investigated the efficacy of total neoadjuvant treatment followed by nonoperative management in patients with locally advanced rectal cancer.
Organ preservation may be a viable option for select patients with locally advanced rectal cancer , according to the first results of the NO-CUT trial.
The NO-CUT trial aimed to assess whether nonoperative management negatively affects the risk for distant relapse and to identify predictive biomarkers of treatment outcomes. David Sebag-Montefiore, MD, who was not involved in the NO-CUT trial, served as a discussant on the findings at the meeting. The NO-CUT trial includes a comprehensive translational program to identify biomarkers predictive of clinical response and survival. ctDNA analysis using the Guardant Reveal assay showed promising results, according to Amatu.
"I do think we are on the verge of a new era for organ preservation. A lot of the groundwork has been done, and we now have a platform to build upon to optimize systemic and radiotherapy-based treatments to change the treatment paradigm," he added.
Colorectal Cancer (CRC) Malignant Rectal Neoplasm Rectal Cancer Cancer Of The Rectum Rectal Carcinoma Cancer Malignant Neoplasia Carcinoma Malignant Neoplasm Neoadjuvant Surgery Organ Preservation Biomarker Biological Marker Multi-Biomarker Disease Activity MBDA Multibiomarker Disease Activity Chemotherapy Italy Italian Radiation Therapy Radiotherapy
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