Efficacy and safety of the two formulations were directly compared in a randomized, controlled, double-blind study of men with AGA conducted in Brazil.
A rigorously conducted trial in men with androgenetic alopecia found that low-dose oral minoxidil was as effective in promoting hair growth as was topical minoxidil.
They were randomized to receive either 5 mg of oral minoxidil a day, plus a placebo solution to apply to the scalp, or topical minoxidil solution applied twice a day plus placebo capsules. They were told to take a capsule at bedtime and to apply 1 mL of the solution to dry hair in the morning and at night.
Dr Friedman said that the study results would not change how he practices, but that it would give him data to use to inform patients who do not want to take oral minoxidil. He generally prescribes the oral form, unless patients do not want to take it or there is a medical contraindication, which he said is rare.
"In real life, not in the clinical trial scenario, it may be very hard for patients to comply with putting on the topical minoxidil twice a day or even once a day," Dr Lipner said.
Facial Rejuvenation Hair Hair Growth Hair Transplantation Hair Replacement Surgery Hair Transplant Alopecia Androgenetic Alopecia Androgenic Alopecia Alopecia Androgenetica Scalp Clinical Research Clinical Trials Clinical Studies Pre-Clinical Trial Double-Blind Study Double-Blind Studies Single-Blind Study Single-Blind Studies Healthcare And Medical Technology
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