No treatment-related interruptions, discontinuations, or serious adverse events were observed with ruxolitinib cream in children aged 2-11 years.
showed good tolerability and was effective over the course of 52 weeks in children aged 2-11 years with atopic dermatitis affecting ≥ 35% or more of their body surface area , results from a small open-label maximum-use trial showed., director of clinical research and division head of dermatology at the Henry Ford Health System, Detroit, said in an interview after the Revolutionizing Atopic Dermatitis conference, wherewas presented during a late-breaking abstract session.
For the current trial, investigators evaluated data on tolerability, safety, systemic exposure, and clinical and patient-reported outcomes through 52 weeks to determine whether clinical benefits and tolerability observed through 8 weeks were sustained. No treatment-related interruptions, discontinuations, or serious adverse events were observed between baseline and week 52. One patient had two treatment-related application site reactions . At weeks 4 and 52, 53.8% of patients achieved treatment success, which was defined as an Investigator Global Assessment of 0/1 with a ≥ 2-grade improvement from baseline. The mean affected BSA decreased from 58.0% at baseline to 11.4% at week 4 and continued to decrease to 2.2% through week 52.
Children Child Childhood Pediatrics Kids Atopic Dermatitis Atopic Eczema Clinical Research Clinical Trials Clinical Studies Pre-Clinical Trial Double-Blind Study Double-Blind Studies Single-Blind Study Single-Blind Studies Eczema Folliculitis Healthcare And Medical Technology Health And Medical Tech Health And Med Tech Health And Medical Technology
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