Study findings show that ivermectin reduces the density of Demodex folliculorum in rosacea lesions, but the skin microbiome takes time to recover.
Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit., but cutaneous dysbiosis remains, according to a report presented at the recent European Academy of Dermatology and Venereology 2023 Congress.
Homey presented the results of a study of 61 patients designed to look at how ivermectin might be working in the treatment of people with rosacea and investigate if there was any relation to the skin microbiome and transcriptome of patients. "The taxa we find within the cutaneous niche of inflammatory lesions of rosacea patients are significantly different from healthy volunteers," Homey said.species are predominant in healthy control persons but are not present when there is inflammation in patients with rosacea. Instead,"Surprisingly, although inflammatory lesions decrease, patients get better, the cutaneous microbiome does not revert to homeostatic conditions during topical ivermectin treatment," he observed.
Homey and associates conclude in their abstract that the findings"support that rosacea lesions are associated with dysbiosis.", professor of dermatology at the University of Coimbra in Portugal, who co-chaired the late-breaking news session where the data were presented, asked whether healthy and affected skin in patients with rosacea had been compared, rather than comparing the skin of rosacea lesions with healthy control samples.
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