The EU court strips TiO₂’s carcinogen label, but experts warn that its DNA-damaging and gut barrier effects remain serious concerns.
), a widely used white pigment found in sunscreens, toothpastes, and paints, is no longer classified as carcinogenic in the EU following a landmark court ruling. The rulingfor its classification. Upholding a 2022 judgement, the court removed the carcinogen label and instructed the Commission to reassess the hazard status of TiO“It remains to be seen how this ruling will influence future hazard assessments by the RAC and the Europe an Commission, as well as the CLP classification process,” confirmed Helge Kramberger-Kaplan, who holds a doctoral degree in engineering and serves as the managing director of Dr.
Robert-Murjahn-Institut GmbH in Ober-Ramstadt, Germany. CLP refers to the EU’s Classification, Labelling and Packaging Regulations for Hazardous Chemicals. Kramberger-Kaplan added, “Ideally, the arguments now confirmed by the ECJ after years of legal dispute would be considered from the outset in future reviews, avoiding further litigation and prolonged uncertainty.”,” said Martin F. Wilks, MD, PhD, former director of the Swiss Centre for Applied Human Toxicology, University of Basel, Basel, Switzerland. “Epidemiological studies of workers involved in TiOby Gerhard Rogler, MD, PhD, head of the Department of Gastroenterology and Hepatology at the University Hospital Zurich and professor at the University of Zurich, both in Zurich, Switzerland, also reported risks: In mice with preexisting intestinal inflammation, TiOnanoparticles worsened symptoms. Rogler observed similar effects in patients with Crohn’s disease, where penetrating particles may weaken the intestinal barrier, trigger inflammatory flare-ups, and increase the risk for cancer over time.’s carcinogenicity,” said Thomas Backhaus, PhD, chair of Ecotoxicology and Environmental Risk Management at the RWTH Aachen University, Aachen, Germany. “None of the plaintiff companies appear to have provided evidence proving that TiOUwe Heinrich, MD, PhD, professor emeritus at Hannover Medical School, and former executive director of the Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany, found no evidence of lung carcinogenicity in rats. However, he noted that the overall data remained insufficient, as“I do not see a carcinogenic risk to the general population from inhalation,” Backhaus stated. “Exposure levels are far too low. The highest exposure is likely from hairsprays, which under current EU rules may contain up to 1.1% TiOKramberger-Kaplan confirmed that “in everyday life, the long-term presence of dust concentrations high enough to cause such effects in human lungs is impossible. Even studies involving thousands of titanium dioxide production workers have found no evidence of harm.”Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our
Toxicity Poisoning Toxins Aesthetic Medicine Facial Rejuvenation Cosmetic Dermatology Cosmetics Inflammatory Bowel Disease IBD Inflammatory Bowel Disease (IBD) Cancer Risk UK Site Content United Kingdom Site Content United Kingdom UK Carcinogen Lung Europe European Crohn' S Disease Crohn Disease Regional Enteritis Crohn’S Cancer Malignant Neoplasia Carcinoma
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