The dual GIP/GLP-1 agonist is the first drug to show benefit in patients with obstructive sleep apnea.
that 40% to 50% no longer needed to use a continuous pressure airway positive device, according to two new studies.-like peptide-1 receptor agonist, also lowered C-reactive protein levels and systolic blood pressure. And patients taking the medication lost 18% to 20% of their body weight.
CPAP is an effective and the most-used intervention for OSA, but many patients refuse to use the device, stop using it, or cannot use it. Should tirzepatide eventually gain US Food and Drug Administration approval for OSA, it would be the first drug approved for the condition. By 1 year, patients taking tirzepatide had 27 to 30 fewer events/hour compared with 4 to 6 fewer events/hour for those taking placebo.
As many as half of patients abandon CPAP therapy within 3 years, writes Patel, who is professor of medicine and epidemiology at the University of Pittsburgh, and medical director of the UPMC Comprehensive Sleep Disorders program."An effective medication to treat obesity is thus an obvious avenue to pursue," he writes.
And, he writes,"Racial disparities in the use of GLP-1 receptor agonists among patients with diabetes arouse concern that the addition of tirzepatide as a treatment option for obstructive sleep apnea without directly addressing policies relative to coverage of care will only further exacerbate already pervasive disparities in clinical care for obstructive sleep apnea."
Obese Sleep Apnea Sleep Apnoea Sleep Disturbance Abnormal Sleep Pattern Sleep Disorder Somnipathy Obstructive Sleep Apnea Obstructive Sleep Apnea Syndrome Obstructive Sleep Apnoea Obstructive Sleep Apnoea Syndrome Sleep Continuous Positive Airway Pressure CPAP GLP-1 Receptor Agonists Glucagon-Like Peptide-1 Receptor Agonists Diabetes Mellitus Type 2 Diabetes Mellitus Type Ii
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