Tirzepatide, a new injectable weight-loss drug, reduced the risk of diabetes in patients with obesity and prediabetes by more than 90% over a three-year period, compared with placebo, according to the results of a new study.
Tirzepatide, a new injectable weight-loss drug with the trade name Zepbound, reduced the risk of diabetes in patients with obesity and prediabetes by more than 90% over a three-year period, compared with placebo, according to the results of a new study led by investigators at Weill Cornell Medicine, NewYork-Presbyterian, Yale School of Medicine and other institutions.
Tirzepatide belongs to a broad new class of drugs that simulate nutrient-stimulated hormones, helping patients lose significant weight and improve their blood sugar control. The drugs work, at least in part, by activating one or multiple receptors throughout the body, including glucagon-like peptide 1 and glucose-dependent insulinotropic peptide receptors on cells in the brain, pancreas and elsewhere.
The trial uncovered no new safety issues; the most common gastrointestinal side effects such as nausea and vomiting decreased as the trial went on, suggesting that long-term use of tirzepatide is relatively tolerable. A follow-up analysis, 17 weeks after stopping treatment, found modest gains in weight and A1c levels, bringing some patients back into the prediabetes and diabetes ranges, and underscoring the likely need for chronic treatment.
Diet And Weight Loss Diseases And Conditions Obesity Personalized Medicine Chronic Illness Wounds And Healing Hormone Disorders
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