During pregnancy, the effects of therapeutical doses of amphetamine have been investigated on birth outcomes in humans. However, a thorough investigation of the mechanisms underlying the long-term effects of embryonal exposure to addictive doses of amphetamine remains largely unexplored.
Using a tiny worm, researchers have revealed the underlying mechanisms of embryonal exposure to methamphetamine and amphetamines, a psychostimulant used to treat a variety of brain dysfunctions.
Using a tiny worm, C. elegans, Florida Atlantic University researchers are the first who investigate the underlying mechanisms within the embryo after exposure to high concentrations of amphetamines, uncovering their long-lasting effects. One advantage of the model the researchers used is that C. elegans embryos can develop outside the uterus and in the absence of maternal care.
"Since our results are in agreement with data showing that mice overexpressing TH exhibit enhanced amphetamine-induced behaviors, and that rats chronically treated with amphetamine exhibit a long-lasting increase in striatal reuptake of dopamine, our findings establish C. elegans as an efficient and inexpensive model to study the long-lasting physiological modifications caused by prenatal exposure to amphetamine," said Carvelli.
Epigenetics Pregnancy And Childbirth Chronic Illness Ecstasy Tinnitus Illegal Drugs Behavior
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