Dr. William A. Haseltine is a distinguished scientist, philanthropist, author, and entrepreneur renowned for his pioneering work in genomics and regenerative medicine. A former Harvard Medical School professor, he has made many significant contributions to cancer and HIV/AIDS research.
What Can Happen To Your Brain And Spine When You Take A Slap Shot To The Neck? A Neurosurgeon ExplainsMemories are created in a matter of seconds. From the moment the brain receives a sensory input , neurons across the brain activate. Connections formed between these neurons give rise to dynamic neural networks called engrams. For example, when exploring a new city, an engram forms and continuously updates as you walk down various streets and turn corners.
When a new memory is being formed, action potentials repeatedly fire from one neuron to another. Increased firing strengthens their connections, making them more efficient and more likely to fire together in the future. This process is driven by synaptic plasticity. Synapses are gaps between neurons that facilitate the transfer of information.
In their study, Jain et. al manipulated the time between sensory inputs to replicate behavioral timescale learning. Specialized biosensors enabled the team to observe microscopic changes at individual synapses within the hippocampus. Their first observation found that disrupting the function of CaMKII enzymes in the long-term potentiation pathway halted learning. This led researchers to speculate that behavioral timescale learning may be mediated by the activity of CaMKII enzymes.
Memory Long Term Potentiation Synapse Alzheimers Engram
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