Ticagrelor monotherapy safely cut bleeding by more than half after intervention for acute coronary syndrome, without an increase in MACCE, in the ULTIMATE-DAPT trial.
for an acute coronary syndrome , dropping aspirin cut bleeding risk without any increase in the risk for ischemic events, new randomized trial results show.
The researchers conclude that "it's time to change the guidelines and it's time to change clinical practice pattern," he said. Most patients with ACS treated with successful PCI using contemporary stents should switch after 1 month from DAPT to monotherapy using a potent P2Y12 inhibitor, "and the best data so far is with ticagrelor.
Visits after PCI were scheduled for 1, 4, 6, and 12 months. The study was double-blind, but unmasking was allowed if knowing the antiplatelet agent was necessary for managing major adverse events. The new results suggest clinicians can safely stop DAPT after a month in this patient population to reduce bleeding risk, and to reduce MACCE they should consider risk stratification, particularly for older patients, said Cheng.
He noted the "absolutely phenomenal" findings regarding MACCE. "There was not a single hint of detection in the difference of MACCE." But although dual antiplatelet therapy effectively mitigates the risk for stent thrombosis and MI, "it is unlikely that the antiplatelet agents diminish the odds of re-stenosis, the main driver of target-vessel revascularization," they add.
ACS - Acute Coronary Syndrome Acute Coronary Syndrome (ACS) Aspirin Acetylsalicylic Acid Thromboembolism Cardiac Surgeries Cardiac Surgery Stroke Cerebrovascular Accident CVA - Cerebrovascular Accident Hemorrhage Bleeding Stent Drug-Eluting Stent Myocardial Infarction Target Vessel Revascularization TVR - Target Vessel Revascularization Thrombosis CV Risk
United States Latest News, United States Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Lower Canadian CPI Brings Rate Cuts Closer While Fed Cuts Appear DelayedCanadian inflation softened more than expected in February, bringing potential rate cuts closer at a time when markets foresee the Fed having to delay its first cut until July
Read more »
Federal Reserve still foresees 3 rate cuts this year but envisions fewer future cutsChair Jerome Powell noted that inflation has cooled considerably but it’s “still too high, ongoing progress in bringing it down is not assured and the path forward is uncertain.”
Read more »
Federal Reserve still foresees 3 rate cuts this year but envisions fewer cuts in futureFederal Reserve officials signaled Wednesday that they still expect to cut their key interest rate three times in 2024 despite signs that inflation was surprisi
Read more »
Federal Reserve still foresees 3 rate cuts this year but envisions fewer cuts in futureThe Associated Press
Read more »
Low LDL With DAPT Tied to High Bleeding Risk After StrokeVery low LDL cholesterol levels may increase the risk of bleeding in patients with stroke who are receiving dual antiplatelet therapy.
Read more »
Pregnant Alexa PenaVega Hospitalized After 3rd Trimester BleedingPregnant Alexa PenaVega is opening up about her recent hospitalization after discovering bleeding during her third trimester
Read more »