Though often prescribed, diuretic pills may not prevent kidneystones nejm
stone recurrence as patients given a placebo. Anywhere from 49% to 59% developed kidney stone symptoms or showed X-ray evidence of a new stone or growth in an old stone.
That amounted to about 100 patients in each group, Alexander said, which may not have been enough to detect differences among them. That means people who have calcium stones and high levels of calcium in their urine: Thiazide diuretics are thought to cut the risk of kidney stones because they reduce calcium excretion into the urine.Gupta also said the specific diuretic regimen was problematic: Hydrochlorothiazide is short-acting, he noted, and patients took it once a day. Instead, Gupta said, a longer-acting diuretic would normally be used, or if hydrochlorothiazide were prescribed, it would be taken twice daily.
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