She’s a workaholic, she’s back home from the city, and she’s run into the ex she’s still obsessed with – but there’s so much more to Somebody I Used To Know than that.
She’s a workaholic, she’s back home from the city, and she’s run into the ex she’s still obsessed with – but there’s so much more toWe, all of us, know every single beat of a classic Hallmark romcom at this point. A career-obsessed woman either heads to a rural retreat and hooks up with a rugged stranger, or she returns to her hometown and rekindles a flame with the ex she left behind there.
It’s not that we don’t enjoy the predictable ebb and flow of these films, it’s just… well, sometimes we like to imagine there’s more to a woman’s life than just these two scenarios. Which is why we’re so excited for Alison Brie and Dave Franco’s new film – especially as it seems set to hold up a lot of those old romcom tropes and do something really smart with them.
United States Latest News, United States Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Jeremy Clarkson: Harry and Meghan accuse TV presenter of spreading 'hate rhetoric' as they dismiss latest apology over Sun columnClarkson said he would usually get somebody to check his Sun articles, but instead wrote the piece in a rush without showing it to anyone. The Sussexes have rejected that explanation and claim he has a track record of hateful articles.
Read more »
Spatiotemporal evolution of the clear cell renal cell carcinoma microenvironment links intra-tumoral heterogeneity to immune escape - Genome MedicineBackground Intratumoral heterogeneity (ITH) is a hallmark of clear cell renal cell carcinoma (ccRCC) that reflects the trajectory of evolution and influences clinical prognosis. Here, we seek to elucidate how ITH and tumor evolution during immune checkpoint inhibitor (ICI) treatment can lead to therapy resistance. Methods Here, we completed a single-arm pilot study to examine the safety and feasibility of neoadjuvant nivolumab in patients with localized RCC. Primary endpoints were safety and feasibility of neoadjuvant nivolumab. Then, we spatiotemporally profiled the genomic and immunophenotypic characteristics of 29 ccRCC patients, including pre- and post-therapy samples from 17 ICI-treated patients. Deep multi-regional whole-exome and transcriptome sequencing were performed on 29 patients at different time points before and after ICI therapy. T cell repertoire was also monitored from tissue and peripheral blood collected from a subset of patients to study T cell clonal expansion during ICI therapy. Results Angiogenesis, lymphocytic infiltration, and myeloid infiltration varied significantly across regions of the same patient, potentially confounding their utility as biomarkers of ICI response. Elevated ITH associated with a constellation of both genomic features (HLA LOH, CDKN2A/B loss) and microenvironmental features, including elevated myeloid expression, reduced peripheral T cell receptor (TCR) diversity, and putative neoantigen depletion. Hypothesizing that ITH may itself play a role in shaping ICI response, we derived a transcriptomic signature associated with neoantigen depletion that strongly associated with response to ICI and targeted therapy treatment in several independent clinical trial cohorts. Conclusions These results argue that genetic and immune heterogeneity jointly co-evolve and influence response to ICI in ccRCC. Our findings have implications for future biomarker development for ICI response across ccRCC and other solid tumors and highlight im
Read more »
Gen3 homologation testing to continue this weekThe Gen3 prototypes are set to run on three of the next seven days as Supercars looks to lock down the homologation of the Ford Mustang and Chevrolet Camaro.
Read more »
Weather forecast as cold snap hits with Met Office warning in placeWeather forecast for Greater Manchester as cold snap hits with Met Office ice warning in place
Read more »
New plans to widen police powers for disruptive protestsOfficers would be able to shut down protests before they cause serious disruption, under new plans.
Read more »
Frijns doubtful for Diriyah FE after breaking wrist in Mexico crashRobin Frijns is likely to miss this month's Diriyah FormulaE race in Saudi Arabia after breaking his wrist in the MexicoCityEPrix on Saturday.
Read more »