I'm a senior editor at Forbes covering healthcare, science, and cutting edge technology. I also co-author the InnovationRX newsletter.
Gordian Biotechnology’s platform allows for potentially hundreds of gene therapies to be tested in an animal at the same time — without harming it.hen developing new therapies for diseases, biotech researchers are often limited by two time-consuming steps: first, screening thousands of drug candidates in test tubes and second, taking the best candidates and testing them on multiple animals to make sure it’s safe and effective. Combined, these steps can be slow and expensive.
“We’ve got a platform that allows us to essentially parallelize the hardest part of the drug discovery process, the animal testing process,” Gordian CEO Francisco LePort toldLePort, 38, cofounded Gordian in 2018 with Martin Borch Jensen, 38, naming the company after the mythical, impossible-to-untangle knot Alexander the Great unraveled by cutting it in half.
Better still, they can often be tested on an animal “without actually affecting the organism,” LePort said. Gordian said that it’s been able to validate its platform through several experiments. For example, in a mouse that had a common liver disease, it tested 50 different gene therapies, 15 of which have already existing clinical data. The company’s program was able to correctly identify 13 of those 15 therapies as potential treatments. The company saw similar accuracy for potential treatments of osteoarthritis in horses.
Pharmaecuticals Biotech Animal Testing In Vivo Aging Longevity Drug Discovery
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