Testing for three biomarkers in a woman's bloodstream could shed light on her risk of developing heart attack, stroke, or other cardiovascular issues decades down the line.
Nick Blackmer is a librarian, fact-checker, and researcher with more than 20 years of experience in consumer-facing health and wellness content.A new study found that testing three biomarkers—CRP, LDL cholesterol, and Lp—in a woman’s bloodstream may be able to predict her risk of experiencing heart attack, stroke, or other cardiovascular issues.
A team of researchers looked at three biomarkers: low-density lipoprotein cholesterol, lipoprotein—also known as Lp—and high-sensitivity C-reactive protein , an indicator of inflammation. They found that the three metrics were related to a woman’s risk of having an adverse cardiovascular event at least 30 years later.
They found that, compared to women who had the lowest levels of these biomarkers, women who had elevated levels were 2.6 times more likely to have a major cardiovascular event. Similarly, elevated levels of LDL cholesterol and Lp have also been previously associated with an increased risk of cardiovascular issues,“LDL or ‘bad cholesterol’ is one of the cholesterol particles which can be responsible for plaque buildup in the arteries in our bodies,” she said. This buildup of plaque makes the arteries more narrow, blocking blood from properly flowing to the heart.
Lp levels are “purely genetic” and can’t be reduced by diet or exercise, Di Pietro added. It’s estimated that one in five people have elevated Lp levels,Along with the three biomarkers included in the study, Paeschke said she uses Apolipoprotein B tests to evaluate her patients’ cardiovascular risk—this is another way to directly measure particles in the blood that might promote plaque formation in the arteries.
Using imaging in combination with bloodwork tests allows doctors to provide an individualized heart health plan for patients so they can be more proactive about their health, Di Pietro said.The results of this new study support universal screening for these three biomarkers, particularly among women. However, routine bloodwork may not include CRP or Lp tests.
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