It’s challenging to make bacteriophages—viruses that infect bacteria—but a new method may ease the burden.
As harmful bacteria increasingly outwit antibiotics, some scientists are turning to a biological weapon to fight them: specialized viruses that slay bacteria. Now, a team of researchers based in Germany offers a potentially faster and better way to create these bacteriophages, or simply phages.
Phages were introduced as a weapon against bacteria more than a century ago. Western medicine abandoned them after the rise of antibiotics, but scientists and doctors in the former Soviet Union.
A startup founded by some of the TUM team members aims to expand the library of phages that phactory can assemble. “The phages described in the paper are relatively small, contrary to most of the phages directed against important multiresistant pathogens,” Ceyssens says. Assembling the larger viruses might prove a challenge, he says, because some phages anchor themselves to the bacterial cell membrane in order to assemble copies.
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