The unknown efficacy of the antiviral drug, tecovirimat, against monkeypox. Read our new fortnightly column, The Clinical Pipeline, from CyrilPedia.
from SIGA Technologies, which produces the antiviral drug. The authors pondered a clinical trial in 2020, but state thatit was considered to be infeasible at the time, due to low patient numbers and challenging field conditions in CAR.”
Adult patients received 600 mg of tecovirimat in oral capsules twice a day for 14 days, with pediatric patients receiving weight-adjusted doses; all patients completed the full course of treatment. One patient died after being discharged with resolved lesions and a negative PCR test, and a second patient, who tested positive for both malaria and HIV, suffered life-threatening anemia.
What it known is that tecovirimat hits its target in vitro in several different orthopoxviruses, including
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