The Scary Link Between Our Molecular Clocks and Alzheimer’s

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The Scary Link Between Our Molecular Clocks and Alzheimer’s
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This link could potentially lead to the development of treatments for age-related neurodegenerative issues such as dementia and Alzheimer’s—but, interestingly, not stroke or Parkinson’s disease.

When it comes to anti-aging science and research, there’s probably no topic more interesting than telomeres. There are caps at the end of chromosomes that act like the plastic bit at the end of a shoelace—keeping our genetic material from getting frayed or tangled. As we age and our cells divide again and again, however, telomeres get shorter and shorter each time. This shortening has been linked to dementia and other age-related conditions.

The findings suggest that the faster a brain ages, the shorter telomeres become. The study’s authors looked at the MRI scans of more than 31,000 participants in the U.K. Biobank . They found that longer telomere length was generally associated with greater “grey matter volumes” in the brain, which also tends to decline with Alzheimer’s; and a thicker cerebral cortex, which typically thins with age.

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