As the use of GLP-1 receptor agonists increases, patients are exploring microdosing—taking lower-than-recommended doses—for a range of reasons including weight maintenance, metabolic health improvements, anti-inflammatory effects, and cost reduction. While proponents highlight its benefits, critics raise concerns about the lack of research, potential contamination, and the uncertainty surrounding compounded GLP-1 formulations.
As glucagon-like peptide 1 receptor agonist use becomes more prevalent, patients are using them for new indications — and at new dosages.
Patients have responded in a big way. On social media platforms, patients tout the appeal of microdosing, trading stories and suggestions for how much to microdose. One reddit thread on GLP-1 microdosing, with 1.7 thousand members, aims to explore the benefits of the medications beyond obesity and diabetes, such as less inflammation and more concentration. At least two Facebook groups devoted to microdosing the medications have formed.
Along with the medications, Koniver advises patients to cut portions and make other lifestyle changes. “We can do telemedicine, as we have a physician licensed in all 50 states. But every patient we see comes in person at some point.” GLP-1 microdosing, in particular, offers a slow and steady way for patients to improve their metabolic health before more serious conditions develop, while minimizing the risk of side effects.
In coming years, long-term studies may show the benefits that GLP-1 and other peptide-based drugs hold for organs affected by obesity, including the liver, pancreas, and kidneys, he said.
GLP-1 Microdosing Telemedicine Obesity Diabetes
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