U.K. researchers gave 36 young, healthy volunteers COVID. What happened next will not shock you, but important discoveries were made nonetheless.
. Real-world exposure to pathogens is often incredibly uncertain, and studying infectious diseases in a well-controlled laboratory setting allows scientists to collect much more data, and do so much more precisely, than would be possible otherwise. For vaccines, this can mean faster, and cheaper, approval.
of the risks to young, healthy participants, COVID HCTs appear to be hundreds of times safer than routine liver donations.For Eyal, this is a decisive piece of evidence in favor of challenge studies, which also may have much greater benefits than a single liver donation. “We certainly wouldn’t let the injuries alone dissuade us from saving a single life through [liver] donation,” Eyal says.
The Imperial researchers are still working to analyze the immunological data from their HCT, so it’s not yet possible to take a full retrospective look at the study’s benefits. What we do know are the negative consequences for the participants.
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