Researchers have looked beyond biochemistry to publish groundbreaking work on the physics of fat droplets found inside many types of cells, revealing them to be a potential threat to a cell's nucleus.They have discovered fat-filled lipid droplets' surprising capability to indent and puncture the nucleus, the organelle which contains and regulates a cell's DNA. The stakes of their findings are high: a ruptured nucleus can lead to elevated DNA damage that is characteristic of many diseases, including cancer.
Fat is a normal and necessary part of the body. Fat cells store and release energy, as well as play significant roles in hormonal regulation and immunity.
The stakes of their findings are high: a ruptured nucleus can lead to elevated DNA damage that is characteristic of many diseases, including cancer. The team's research reframes scientific inquiry into fat, underlining that fat's role in the body is much more than just a number on the scales.
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