The association of BNT16B2b2 mRNA COVID-19 vaccine with thrombocytopenia and pneumonitis: A case report mRNA vaccine vaccination COVID19 coronavirus covid
By Dr. Priyom Bose, Ph.D.Oct 11 2022Reviewed by Benedette Cuffari, M.Sc. Side effects associated with the coronavirus disease 2019 vaccination have been reported in many countries. Thrombocytopenia is not uncommon; however, pneumonitis induced by vaccination is relatively rare, with only five cases that have been reported to date.
About the patient The subject of the current study was an 80-year-old Japanese man who experienced seven days of cough, fever, and shortness of breath. The individual also had a history of Behçet’s disease and hypertension but was not under any medication. At the hospital, the patient’s body temperature was 38°C and C-reactive protein levels were 158.0 mg/L, which normally has a reference value of 1.4 mg/L. Both CRP and temperature levels eventually normalized. The patient subsequently received the second vaccine dose after three weeks of receiving the first.
Treatment Related StoriesThe patient received a diagnosis of community-acquired pneumonia and was subsequently treated with 2 g/day of ceftriaxone. The response was not satisfactory, which led the clinicians to then initiate levofloxacin and tazobactam/piperacillin treatment. Nevertheless, the fever did not subside, with CRP and blood cell counts remaining elevated.
Platelet counts ultimately returned to normal after five days, thus allowing the prednisolone dose to be reduced after eight days. CT images after three weeks showed an improvement in lymph node appearance and pneumonia. After the completion of steroid tapering, the subject continues to do well and is periodically monitored.
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