Nature research paper: TET2 guards against unchecked BATF3-induced CAR T cell expansion
Rv-1928z+41BBL cells. The exogenous cytokine supplement had to be stopped at day 60 due to deteriorating mice condition in response to frequent injections., CAR T cell quantification in peripheral blood under different exogenous supplementation at day 30, day 60 and day 75.
Each dot represents a mouse. UD: undetected. Data is represented as mean±SD ., CAR T cell quantification in bone marrow and spleen at day 150 post CAR T cell infusion. Data is represented as mean±SD . p values were determined by two-sided Mann–Whitney test . p 0.05, not significant, NS; *, p < 0.05; **, p < 0.01. (
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