A research team describes how they engineered an efficient new enzyme that can produce a synthetic genetic material called threose nucleic acid.
The ability to synthesize artificial chains of TNA, which is inherently more stable than DNA, advances the discovery of potentially more powerful, precise therapeutic options to treat cancer and autoimmune, metabolic and infectious diseases.
"This achievement represents a major milestone in the evolution of synthetic biology and opens up exciting possibilities for new therapeutic applications by significantly narrowing the performance gap between natural and artificial enzyme systems," said corresponding author John Chaput, UC Irvine professor of pharmaceutical sciences.
Other UC Irvine team members were graduate students Victoria A. Maola, Eric J. Yik and Mohammad Hajjar; project scientist Nicholas Chim; and undergraduates Joy J. Lee, Kalvin K. Nguyen, Jenny V. Medina, Riley N. Quijano, Manuel J. Holguin and Katherine L. Ho -- all from the Department of Pharmaceutical Sciences.
Pharmacology Human Biology Biochemistry Research Biology Biotechnology And Bioengineering Organic Chemistry Biochemistry Materials Science
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