The Tasmanian tiger has a long, checkered history that now includes being the first extinct animal family from which scientists have recovered RNA, the molecule that brings a species' genome to life.
Recovering RNA – the genetic material that translates the information encoded in DNA into proteins – from extinct animals like the thylacine could open a trove of information on gene activity"The recovery of RNA expression profiles no longer existing in living cells expands the possibility of delving into the biology of extinct animals," bioinformatician Emilio Mármol-Sánchez of Stockholm University and colleagues"This is the first time that we have had a glimpse into...
[went] extinct more than one century ago",While reading sequences of DNA tells us what genes a species has, RNA sequences reveal which genes are actually 'switched on' and used to make proteins inside cells. But RNA is far more fragile and breaks downMármol-Sánchez and colleagues took six muscle and skin samples from a thylacine specimen that was catalogued in 1891 and shelved at the Natural History Museum in Stockholm.
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