The 49ers have had the Rams number. Back the 49ers at +3.5 and take them on the moneyline (+145 at Bet MGM) as well.
A common narrative you’ll likely hear this weekend is that it’s hard to beat a team three times in one season. Despite this being conventional wisdom to many people, it’s simply not true.
The 49ers defeated the Rams twice in the 2021 season. San Francisco has dominated Los Angeles in the Kyle Shanahan vs. Sean McVay era — the Niners are 7-3 against the Rams since 2017, winning the past six matchups, with the past four victories coming as underdogs. Under Shanahan, the 49ers have thrived as underdogs with a 25-17 record against the spread , per our Action Labs data. It’s a role they’re very familiar with, as they’re coming off three straight wins as underdogs. They needed to win on the road at the Rams in Week 18 to make the playoffs before defeating the Cowboys in Dallas and the Packers in Green Bay to advance to their second NFC Championship Game in the last three seasons.
Matthew Stafford struggled to close out the regular season, throwing eight interceptions and fumbling once in the final four games. In the postseason, he’s looked completely rejuvenated, completing 74.5 percent of his passes for 568 yards and four touchdowns with no turnovers. That said, Stafford will face a much tougher matchup against Nick Bosa, Arik Armstead, Fred Warner and a 49ers defense that can generate pressure without blitzing.
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