Study shows no undetected monkeypox virus transmission before May 2022 in Rotterdam and Amsterdam medrxivpreprint ErasmusMC Monkeypox MonkeypoxInfection Amsterdam Rotterdam Transmission Virus
By Pooja Toshniwal PahariaNov 23 2022Reviewed by Aimee Molineux In a recent study posted to the medRxiv* preprint server, researchers investigated whether undetected human monkeypox virus transmission occurred before the first documented MPX case in Rotterdam and Amsterdam.
In total, 401 anorectal specimens and ulcer specimens obtained from males who have sex with male individuals visiting the Centers for Sexual Health of Rotterdam and Amsterdam dated back to February 14 were analyzed. The CSH regularly obtains the anorectal specimens for Ct and Ng testing. In contrast, ulcer specimens are obtained for VZV , Tp , and HSV -1, -2 testing. All specimens were preserved for four months.
Results Related StoriesIn Amsterdam, 169 Ng/Ct-positive anorectal specimens and 125 ulcer specimens were tested for hMPXV presence. None of the specimens were hMPXV-positive. In Rotterdam, 93 Ct/Ng-positive anorectal specimens were tested, of which 30 visitors reported complaints between 1 April and 18 May 18. In addition, during the period, 12 ulcer specimens were tested for hMPXV presence.
Sequences of the hMPXV-positive Amsterdam MSM individual were identified to be IIb clade sequences and were closely related to global hMPXV strains. The hMPXV-positive Rotterdam resident sequences could not be analyzed due to insufficient deoxyribonucleic acid . The two hMPXV-positive cases were identified in a period coinciding with that of initial MPX case documentation in Spain , Portugal , and the United Kingdom .
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