Researchers have discovered a more accurate and timely way to deliver life-saving drug therapies to the brain, laying the groundwork for more effective treatment of brain tumors and other neurological diseases. Investigators used an electric field to infuse medicine from a reservoir outside the brain to specific targets inside the brain.
Houston Methodist researchers have discovered a more accurate and timely way to deliver life-saving drug therapies to the brain, laying the groundwork for more effective treatment of brain tumor s and other neurological diseases., an open access journal from Nature Portfolio, investigators used an electric field to infuse medicine from a reservoir outside the brain to specific targets inside the brain.
"Delivering therapeutics by way of ECED has many applications," explained Dr. Amir Faraji, principal investigator and Houston Methodist neurosurgeon."It has the potential to improve gene therapy and tumor treatment, as well as treatment for traumatic brain injury and degenerative diseases -- any number of situations where we need to get vital treatments to the brain in a more targeted manner.
A"Behind the Paper" blog on the study -- by Houston Methodist research scientist and co-author Jesus G. Cruz-Garza -- explains how ECED can infuse macromolecules into the brain from a hydrogel reservoir placed at the brain's surface. This project was supported by the Houston Methodist Foundation and the Houston Methodist Research Institute Clinician-Scientist Award. It also received philanthropic funding from Paula and Rusty Walter and Walter Oil & Gas Corp Endowment at Houston Methodist: the John S."Steve" Dunn, Jr. & Dagmar Dunn Pickens Gipe Chair in Brain Tumor Research; and grant number RP190587 from the Cancer Prevention and Research Initiative .
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