The genetic relationship between body mass index (BMI) and multiple neurological diseases.
By Dr. Sushama R. Chaphalkar, PhD.Mar 29 2024Reviewed by Lily Ramsey, LLM In a recent study published in Scientific Reports, researchers from China used Mendelian randomization to assess the genetic relationship between body mass index and multiple neurological diseases.
Neurological diseases cover a broad spectrum of nervous system conditions, including neurodegenerative, cerebrovascular, infectious, oncological, and hereditary disorders. Therefore, researchers in the present study investigated the genetic links between BMI and neurological diseases using MR analysis, aiming to inform disease management strategies.
Data for various neurological diseases were sourced from the IEU database, including PD, AD, MS, ALS, IS, EP cases, and respective control groups. Results and discussion As per the study, significant genome-wide associations were found between BMI indicators and SNPs for PD , AD , MS , ALS , IS , and EP . The IVW analysis showed no genetic causality between BMI and PD, AD, ALS, and epilepsy .
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