In findings with implications for future therapies in chronic kidney disease, mouse studies show a protective effect of glucagon receptor signaling in the kidney.
Glucagon is a pancreatic hormone that fluctuates extensively with fasting and feeding states and interacts with GCGRs in the liver to regulate blood glucose levels and carbohydrate, lipid, and protein metabolism.
To understand the role of kidney GCGRs in normal renal function, researchers generated two new lines of mutant mice lacking GCGRs in the kidneys and compared them with mice without genetic manipulations and those with GCGRs deleted in the liver.
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