Study reveals alarming global burden of antimicrobial resistance in bacterial infections AntimicrobialResistance AMR GlobalHealth PublicHealth InfectiousDiseases BacterialInfections Healthcare Research DataGaps TheLancet
By Neha MathurApr 23 2023Reviewed by Danielle Ellis, B.Sc. In a recent article published in the Lancet journal, researchers quantified the global bacterial antimicrobial resistance burden to present deaths and disability-adjusted life-years attributable to and associated with 23 pathogens, 12 major infectious syndromes, 18 drug categories, and 88 pathogen–drug combinations.
The World Health Organization and numerous other researchers have also raised that AMR spread is a pressing issue that needs immediate attention; if left unaddressed, rising AMR will make several bacterial pathogens highly fatal in the near future. The challenge is to gather current data on pathogen–drug combinations contributing to actual bacterial AMR burden for all world regions, even those with minimal surveillance.
They retrieved data from published scientific literature, multisite research collaborations, clinical trials, research institutes based in low-income and middle-income countries , public and private hospital records, diagnostic testing data, surveillance systems of pharmaceutical companies, global, national, and enhanced surveillance systems, and other relevant sources, encompassing 471 million patient records or isolates and 7,585 study-location years, which they gathered using varied...
Study findings Substituting drug-resistant infections by no infections and susceptible infections would have saved 4.95MN and 1.27MN deaths, respectively, in 2019, implying that in 2019, the global AMR burden related to drug-resistant infections for 88 pathogen–drug combinations was ~4.95MN deaths , of which drug resistance alone caused 1.27MN deaths. Moreover, after ischaemic heart disease and stroke, AMR accounted for most deaths in 2019.
Seven pathogen–drug combinations caused more than 50000 deaths, highlighting the need for expanding infection prevention and control policies targeting the deadliest combinations, bolstering vaccine and antibiotic development, and improving access to essential second-line antibiotics where needed. Furthermore, resistance to β-lactam antibiotics, e.g., penicillins and cephalosporins, and fluoroquinolones accounted for >70% of deaths attributable to AMR across pathogens.
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