New research from the Lippincott-Schwartz Lab at HHMI's Janelia Research Campus being presented at Cell Bio 2022 provides a close-up look at the individual molecules that facilitate communication between cellular structures. The new research, which is also posted as a preprint on bioRxiv, shows that these molecular tethers are much more dynamic and complex than previously thought, revealing new insights about their role in helping to keep cells alive.
The researchers found these tethers are in constant motion, remaining at the contact site for only a few seconds before being exchanged with other tethers. The tethers are continuously binding and unbinding organelles together and altering the size and configuration of the contact site in response to changes in the cell.
Single particle tracking-photoactivation localization microscopy follows the motion of individual tether molecules, while simultaneously capturing the location of the ER and mitochondria. Credit: Obara et al.can react to changes so quickly and suggest these molecular tethers could act as modular communication hubs for coordinating cell physiology.
The new findings show the importance of dynamic cell imaging and could help in understanding some neurodegenerative disorders. The new research suggests a mutation associated with ALS affects a tether's ability to bind and unbind at the contact site, potentially perturbing effective cellular communication.
Single particle tracking-photoactivation localization microscopy analysis shows how single organelle tether molecules behave before and after contact site interaction. Even within a short time window, many different tether molecules explored each contact site. The tether molecules resided within a contact site only briefly, with most molecules leaving the site within a few seconds. Credit: Obara et al.Christopher J.
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