A new study identified that a semi-synthetic compound can be derived from natural compounds and shows potent activity against tuberculosis (TB), including multi-drug resistant TB.
A new study identified that a semi-synthetic compound can be derived from natural compounds and shows potent activity against tuberculosis , including multi-drug resistant TB., the pathogen responsible for tuberculosis , is the leading cause of bacterial disease-related death worldwide. Current antibiotic regimens for the treatment of TB are dated, require longer courses of treatment and risk the development of drug-resistance.that could also be effective against drug-resistant strains.
The group of researchers redesigned sanguinarine using principles of medicinal chemistry to produce a more potent antibacterial compound with reduced toxicity. In studies in test tubes and in mice, the improved version of sanguinarine, called BPD-9, was capable of killing strains ofthat are resistant to all front-line antibiotics used in the clinics to treat TB.
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