Study highlights the emergence of S. cerevisiae as an opportunistic fungal pathogen in immunosuppressed patients presenting several severe comorbidities TropicalmedMDPI pathogen disease immunosuppressed
By Dr. Chinta SidharthanFeb 7 2023Reviewed by Danielle Ellis, B.Sc. In a recent study published in Tropical Medicine and Infectious Disease, a team of researchers from Brazil presented a fatal case of a patient developing Saccharomyces cerevisiae infection and succumbing to septic shock after contracting and recovering from a severe acute respiratory syndrome coronavirus 2 infection.
A recent increase in Saccharomyces infections has been observed among critically ill patients, which is thought to be linked to the probiotic dietary supplements given to ease diarrhea caused by antibiotics. Given the increasing risk of Saccharomyces infections among immunocompromised and critically ill patients, its virulence needs further investigation.
Results The case report indicated that the patient had a history of smoking, systemic arterial hypertension, and stroke with aphasia. Positive SARS-CoV-2 polymerase chain reaction tests 30 and 10 days before hospital admission indicated COVID-19, which was treated at home symptomatically. Five antifungals — amphotericin B, caspofungin, fluconazole, 5-flucytosine, and voriconazole — were tested against the strain, and for all five, the strain displayed low minimal inhibitory concentrations, indicating that it was susceptible. However, the fungal strain was able to produce biofilms and virulence factors, including extracellular bioactive molecules such as aspartic peptidase, catalase, esterase, hemolysin, phospholipase, phytase, and siderophore.
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