Study finds no benefits from angiotensin receptor blocker treatment for COVID-19 AngiotensinReceptor Coronavirus Disease COVID bmj_latest
Study: Angiotensin receptor blockers for the treatment of covid-19: pragmatic, adaptive, multicentre, phase 3, randomised controlled trial. Image Credit: Kateryna Kon / Shutterstock
About the study In the present study, the researchers conducted a randomized, pragmatic, multicenter, double-blinded, controlled phase three trial called CLARITY. Individuals 18 years old or above with laboratory-confirmed SARS-CoV-2 infections and who needed hospitalization were recruited for the study from 17 locations in India and Australia.
Related StoriesThe participants in India were administered a 40 mg dose of the angiotensin receptor blocker telmisartan for 28 days or a matched placebo. In Australia, physicians chose which angiotensin receptor blocker to use. Due to the unavailability of a placebo in the Australian sites, the study was not double-blinded in Australia. Follow-up was carried out telephonically with the patients after discharge, and trial data were collected from medical records.
The participants exhibited milder symptoms than were anticipated at the onset of the study, with close to 75% of the patients being discharged in a week and more than 90% being discharged after two weeks. The patients in the trial were also younger than those in other reported trials, which could explain the low severity of the disease.
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Risk for newly diagnosed diabetes after COVID-19: a systematic review and meta-analysis - BMC MedicineBackground There is growing evidence that patients recovering after a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may have a variety of acute sequelae including newly diagnosed diabetes. However, the risk of diabetes in the post-acute phase is unclear. To solve this question, we aimed to determine if there was any association between status post-coronavirus disease (COVID-19) infection and a new diagnosis of diabetes. Methods We performed a systematic review and meta-analysis of cohort studies assessing new-onset diabetes after COVID-19. PubMed, Embase, Web of Science, and Cochrane databases were all searched from inception to June 10, 2022. Three evaluators independently extracted individual study data and assessed the risk of bias. Random-effects models estimated the pooled incidence and relative risk (RR) of diabetes compared to non-COVID-19 after COVID-19. Results Nine studies with nearly 40 million participants were included. Overall, the incidence of diabetes after COVID-19 was 15.53 (7.91–25.64) per 1000 person-years, and the relative risk of diabetes after COVID-19 infection was elevated (RR 1.62 [1.45–1.80]). The relative risk of type 1 diabetes was RR=1.48 (1.26–1.75) and type 2 diabetes was RR=1.70 (1.32–2.19), compared to non-COVID-19 patients. At all ages, there was a statistically significant positive association between infection with COVID-19 and the risk of diabetes: 65 years: RR=1.68 (1.22–2.30). The relative risk of diabetes in different gender groups was about 2 (males: RR=2.08 [1.27–3.40]; females: RR=1.99 [1.47–2.80]). The risk of diabetes increased 1.17-fold (1.02–1.34) after COVID-19 infection compared to patients with general upper respiratory tract infections. Patients with severe COVID-19 were at higher risk (RR=1.67 [1.25–2.23]) of diabetes after COVID-19. The risk (RR=1.95 [1.85–2.06]) of diabetes was highest in the first 3 months after COVID-19. These results remained after taking confounding factors into acco
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