No adverse events were observed in a small retrospective study of pediatric patients receiving the MMRV vaccine while on dupilumab or methotrexate.
A retrospective analysis finds no adverse events in children receiving a live attenuated vaccine against measles, mumps, rubella, and varicella while on dupilumab or methotrexate treatment, challenging current recommendations.Researchers conducted a retrospective search of electronic medical records at a pediatric tertiary care center between 2017 and 2023, identifying patients who received dupilumab or methotrexate for allergic or dermatologic concerns.
The analysis included pediatric patients who received live attenuated vaccines within 6 weeks before initiating or up to 6 weeks after ending treatment with either medication.A total of 313 pediatric patients who were treated with dupilumab or methotrexate during the study period were identified. Five patients received an MMRV vaccine while on dupilumab, and four received it while on methotrexate treatment.“Larger, prospective studies are needed to establish evidence-based recommendations for safe and effective use of live virus vaccines in children treated with methotrexate, dupilumab, and other medications impacting immune function,” the authors wrote.
This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC. This website also contains material copyrighted by 3rd parties.
Vaccines Children Child Childhood Pediatrics Kids Pediatric Dermatology Pediatric Respiratory Infections Pediatric Respiratory Syncytial Virus Infection Pediatric RSV Infection Pediatric Cold
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